Volume 8

Number 2 July 2024

Expression of BCL-2 in Renal Cell Carcinoma and Its Association with Histopathological Grade

DOI: https://doi.org/10.70357/jdamc.2024.v0802.03

Anjum M1 , Nasrin M2 , Hossain S3 , Hasan MZ4 , Snigdha SS5 , Jeba R6 , Khan RR7 , Hossain MS8 , Hossain MF9

Abstract

Background: Renal cell carcinoma (RCC) is a quite common cancer worldwide and it is difficult to determineprognosis only with staging and grading as spontaneous metastasis or late metastasis can occur after curative surgery.BCL-2, an apoptosis inhibitor gene expression is randomly found in specimen of RCC. Over expression of BCL-2 can help in determining the progression of RCC. 

Aim: The aim of the study was to determine the expressionof BCL-2 in histopathologically diagnosed renal cell carcinoma and its association with histopathological grade.

Materials and methods: This cross-sectional study was conducted in the Department of Pathology, Dhaka MedicalCollege, Dhaka, from March 2021 to February 2023 among purposively included 60 histopathologically diagnosedRCC patients. After taking informed written consent data were collected by face-to-face interview-medical recordsreviewing by using a pretested semi-structured questionnaire and check list. Immuno-staining with BCL-2 antibodywas also done and findings were recorded. Statistical analysis was carried out using the SPSS software version 25.

Results: The mean±SD age of the patients was 57.2 (±11.7) years, majority 20 (33.3%) were within 55-64 years ofage and majority 42 (70%) patients were male. Regarding histopathological type, majority 44 (73.4%) had clear celltype followed by papillary 14 (23.3%) and chromophobe 2 (3.3%) type of RCC. According to ISUP grade, majority31 (51.6%) belonged to grade 2 followed by 15 (25%), 10 (16.7%) and 4 (6.7%) patients belonged grade 1, grade 3and grade 4 RCC respectively. Positive expression of BCL-2 was detected in 37 (61.7%) of cases while negative BCL-2 expression was detected in 23 (38.3%) of patients. Significant statistical association was present between BCL-2expression with grading of RCC (p<0.05). 

Conclusion: BCL-2 expression was positive in about two-third of renal cellcarcinoma patients and expression was more frequent among patients with low grade RCC

Keywords:


  1. Assistant Professor, Department of Pathology

    Marks Medical College, Mirpur

  2. Medical Officer, Department of Pathology

    Mugda Medical College, Dhaka

  3. Pathologist

    Dhaka Medical College, Dhaka

  4. Lecturer, Department of Pathology

    Shaheed Tajuddin Ahmed Medical College, Gazipur

  5. Assistant Professor Department of Pathology

    ZH Sikder Women’s Medical College & Hospital, Dhaka

  6. Professor and Head Department of Pathology

    Dhaka Medical College, Dhaka

  7. Assistant Professor Department of Pathology

    Dhaka Medical College, Dhaka

  • Department of Pathology

    Dhaka Medical College, Dhaka

  • Assistant professor Department of Glaucoma

    National Institute of Opthalmology & Hospital Sher- E- Bangla Nagar, Dhaka

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    Volume 8, Number 2 July 2024
    Page: 8-14