The aim of the study was to compare the efficacy and compliance of methyldopa and labetalol in controlling blood pressure inpregnancy induced hypertension (PIH). A total of 120 patients having pregnancy induced hypertension (PIH) were taken anddivided in to two groups. Group A was given Tab. Methyldopa 250mg and group B Tab. Labetalol 100 mg. In both the groupsnd th stpre and post treatment blood pressure was measured on day 2 , 7 and day 21 was compared. Reduction of blood pressure andside effects of methyldopa and labetalol were observed. The mean pre treatment blood pressure in group A was 157/104±10th th stmmHg which was reduced to 137/89±10 mmHg on 48 hours, 127/85±10 mmHg by 7 day and 120/78±10 mmHg by the 21thday. In group B mean pre treatment blood pressure was 162/108±10 mmHg which was reduced to 130/84±10 mmHg on 48sthours, 122/80±10 mmHg by 7th day and 115/74±10 mmHg by the 21 day. Methyldopa and Labetalol have effectivelycontrolled the blood pressure in pregnancy induced hypertensive patients. The level of blood pressure in pregnancy inducedhypertensive patients in both Methyldopa and Labetalol treated groups were significantly reduced after intervention but nostatistically significant difference was observed between the two groups. The present study indicates that both Methyldopa andLabetalol reduced the blood pressure in PIH patients.