Volume 3
Number 2 July 2019Bartter Syndrome
DOI: https://doi.org/10.70357/jdamc.2019.v0302.07
Saha B K1 , Akter T2 , Rahman M3 , Rima Z A4 , Biswas B K5
Abstract
In 1962 Bartter et al. described a new disease entity in two African American who presented with metabolic alkalosis,hyperplasia of juxtaglomerular apparatus, and normotensive hyperaldosteronism. Over the years, several phenotypic andgenotypic variants of the original descriptions of Bartters syndrome (BS) have been identified. It is an uncommon inheritedrenal tubular disorder with hyponatremia, hypokalemia, hypochloremic metabolic alkalosis, hypereninemia with normalblood pressure associated with increased urinary loss of sodium, potassium, calcium and chloride. A history of consanguineousmarriage is present in many families. Most cases of BS are present in neonates. Prenatally, neonatal BS can be diagnosed byfinding elevated amniotic fluid chloride and aldosterone levels.
Keywords: Bartter Syndrome, Metabolic disorder, Inherited renal tubular disorder.
- Assistant Professor, Department of Paediatrics
- Associate Professor, Department of Paediatrics
- Registrar, Department of Paediatrics
- Assistant Registrar, Department of Paediatrics
- Professor & Head, Department of Paediatrics