Background: HSV-2 is a common human pathogen that leads to lifelong latent infection. Infection with HSV-2 is one of the most common sexually transmitted infections. Maternal infections may be associated with transmission to the fetus as the infection is common in women of reproductive age. It can be contracted and transmitted to the fetus during pregnancy and the newborn. The greatest risk for miscarriage, premature labour, inhibited fetal growth or transmission of the herpes infection to the infant cause of neonatal infection, which can lead to death or long-term disabilities.

Objective: To estimate IgG antibody to Herpes Simplex Virus type 2 in women with spontaneous abortion and women with normal delivery.

Methods: This Cross-sectional study carried out among 40 patients (group-I) with spontaneous abortion and 40 patients (group-II) of normal delivery attended at the department of Obs & Gynae, Gonoshasthaya Samaj Vittik Medical College Hospital, Savar, Dhaka, Bangladesh for a period of 1 years from July 2015 to June 2016. Laboratory facilities were availed from the Molecular Biology Laboratory, Institute of Biological Sciences, the University of Rajshahi, Bangladesh and the Department of Microbiology, Gonoshasthaya Samaj Vittik Medical College & Hospital.

Results: The mean age was found 25.5±5.7 years in group I and 25.2±5.5 years in group II. The mean age was not statistically significant (p>0.05) between two groups. Anti-HSV-2-IgG was found among 10(25%) women with spontaneous abortion (group I) and 7(17.5%) women with normal delivery (group II). The difference of the result was not statistically significant
(p>0.05) between two groups. The highest rate of past history of abortion was found in 6(37.5%) cases out of total 16 seropositive women with spontaneous abortion group (group I). History of abortion was higher in spontaneous abortion group (group I) but not statistically significant (p>0.05).

Conclusion: The seroprevalence of HSV-2 was relatively high in women with spontaneous abortion. Sero positive HSV-2 antibodies occurred at highest rate in age group 18-23 years old in both group.