Volume 6

Number 1 January 2022

Antioxidant Status in Type-2 Diabetes Mellitus Compared to Diabetic Foot Patients- A Hospital Based Study in Rajshahi

DOI: https://doi.org/10.70357/jdamc.2022.v0601.02

Alam T1 , Habib A2 , Rahman MA3 , Hossain MI4 , Haque L5 , Akter A6

Abstract

Background: Chronic hyperglycemia in diabetes mellitus leads to decrease total antioxidant level in the body which mightplay important role in the development of chronic complications of diabetes due to oxidative stress.

Objective: It is aimed to evaluate the antioxidant status in type-2 diabetes mellitus patients & diabetic foot patients.

Methods: This was a descriptive cross sectional study carried out in the department of Pharmacology & Therapeutics incollaboration with Rajshahi Diabetic Association General Hospital, Rajshahi from July 2017 to June 2018 to evaluate totalantioxidant status in type-2 diabetes mellitus. In this study, 20 patients with type-2 diabetes mellitus and 20 diabetic footpatients were evaluated. Antioxidant status was determined by using spectrophotometer. Most of the patients were age ranging40-60 years of both sexes.

Results: The mean of fasting blood glucose and total antioxidant capacity of type-2 diabetes mellitus with diabetic footpatients was 11.23+/-2.76 mmol/l and 18.78+/-6.70 μmol/l and that of type-2 DM patients was 9.13+/-2.57 mmol/l and 26.07+/-7.67μmol/l. Antioxidant level were less in type 2 diabetic foot patients.

Conclusion: There is low level of antioxidant in plasma which may be regarded as an important causative factor fordevelopment of type-2 diabetes mellitus and its chronic complication. The findings can be a basis of generating a hypothesis forfurther testing towards a meaningful conclusion.

Keywords: Antioxidant status, type-2 diabetes mellitus, Diabetic foot


  1. Assistant Professor Department of Pharmacology & Therapeutics

    Ad-Din Akij Medical College, Khulna

  2. Retired Professor, Department of Pharmacology & Therapeutics

    Rajshahi Medical College, Rajshah

  3. Associate Professor, Department of Anatomy

    Ad-Din Akij Medical College, Khulna

  4. Associate Professor, Department of Pharmacology & Therapeutics

    Naugaon Medical College, Naugaon

  5. Assistant Professor, Department of Pharmacology & Therapeutics

    Rajshahi Medical College, Rajshahi

  6. Assistant Professor, Department of Pharmacology & Therapeutics

    Kumudini Women's Medical College, Mirzapur, Tangail

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Volume 6, Number 1 January 2022
Page: 6-9