Volume 6

Number 2 July 2022

Serum C-reactive Protein & Ferritin Level in Patients with Maintenance Hemodialysis

DOI: https://doi.org/10.70357/jdamc.2022.v0602.04

Sadat MN1 , Shahnaj A2 , Tymee S3 , Leera FBA4 , Parvin S5 , Mohaimen AA6 , Manzur MR7

Abstract

Background: Hemodialysis is the widely used renal replacement therapy for end stage renal disease. Chronic inflammation isvery common in patients with maintenance hemodialysis. There are several markers to assess the inflammatory status. Some ofthese markers strongly predict the mortality & morbidity among these patients.

Objectives: This study was carried out to determine serum C-reactive protein and ferritin level inpatients with maintenancehemodialysis (MHD).

Methods: This cross-sectional study was carried out in the Department of Biochemistry, Dhaka medical college, Dhaka fromthe period of July 2018 to June2019. In this study, thirty patients on MHD were taken from the dialysis unit,Department of Nephrology, Dhaka Medical College Hospital, Dhaka. For betterassessment another age and sex matched thirty healthyindividual were also taken.SerumCRP and ferritin level of all participants were measured and all values wereanalyzedstatistically.

Results: Serum C-reactive protein level was found to be higher than normal in 70%of MHD patients. Median CRP level wassignificantlyhigher in hemodialysis group (13.9 mg/L) when compared with controls (1.74 mg/L). 80% MHD patient hadserum ferritin value >500 μg/L. Median serum ferritin level was alsosignificantly higher in hemodialysis patients comparedwith controls (1342 μg/L vs 51 μg/L). Serum CRP had significant positivecorrelation with serum ferritin in high CRP group ofMHD patients (r= 0.658, p= 0.001).

Conclusion: Serum CRP and ferritin level were higher in MHD patients than control. Serum CRP had linear positive relationwith serum ferritin in MHD patients having high CRP value.

Keywords: Maintenance hemodialysis, C-reactive protein, Ferritin


  1. Assistant Professor, Department of Biochemistry

    Diabetic Association Medical College, Faridpur

  2. Associate Professor, Department of Biochemistry

    Dhaka Medical College, Dhaka

  3. Assistant Professor, Department of Biochemistry

    Sher-E-Bangla Medical College, Barishal

  4. Assistant Professor, Department of Biochemistry

    Bashundhara Ad din Medical College

  5. Assistant Professor, Department of Pathology

    Diabetic Association Medical College, Faridpur

  6. Assistant Professor, Department of Biochemistry

    Rajshahi Medical College

  7. Lecturer, Department of Biochemistry

    Chittagong Medical College, Chattagram

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Volume 6, Number 2 July 2022
Page: 16-20