Objectives: We observe that clinically apparent seborrheic keratoses may be associated with some form of histologically proven skin malignancy. The case represents a 70-year-old male who presented with clinically typical seborrhoeic keratosisthat later histological examination showed partially covered squamous cell carcinoma.

Methods: Clinical information was obtained from the patient's medical records. Five to eight H&E-stained sections wereavailable for evaluation of this case.

Findings: Histopathology of the lesion revealed thickened epidermis with full-thickness dysplasia, hyperchromatic nuclei,and abnormal mitoses with areas of maturation forming parakeratotic horny pearls and individually keratinized cells,confirming the diagnosis of squamous cell carcinoma.

Conclusions: The rapid growth or transformation of seborrheic keratosis may be a sign of the appearance of squamous cellcarcinoma.Keywords: Squamous Cell Carcinoma, Seborrhoeic Keratosis